*Click test name for more information including; Specimen Requirements, Storage and Transport, Specimen Rejection Criteria, Turn around Time and CPT codes.
| Test Name | Methodology | Test Description | Specimen Requirements | Storage and Transport | Specimen Rejection Criteria | Turn Around Time (TAT) | CPT Codes* |
|---|---|---|---|---|---|---|---|
| UroVysion Bladder Cancer FISH | FISH | Cytogenetic studies reveal frequent alterations of a variety of chromosomes associated with bladder carcinoma including chromosomes 1, 3, ,5, 7, 9, 10, 17, and others. The UroVysion Bladder Cancer Kit (UroVysion Kit) is designed to detect aneuploidy for chromosomes 3, 7, 17, and loss of the 9p21 locus via fluorescence in situ hybridization (FISH) in urine specimens from persons with hematuria suspected of having bladder cancer. Results from the UroVysion Kit are intended for use, in conjunction with and not in lieu of current standard diagnostic procedures, as an aid for initial diagnosis of bladder carcinoma in patients with hematuria and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer. |
Voided urine mixed 2:1 (v:v) with recommended PreservCyt (Hologic) or NuCyte fixative. |
Specimen should be stored and transported refrigerated with a cool pack. |
3 - 5 Days |
88120 |
|
| PDGFRβ | FISH | •Disease(s): Myeloid neoplasms associated with eosinophilia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| TCL2A | FISH | •Disease(s): T-Cell Lymphoma |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| ALK | FISH | •Disease(s): T-anaplastic large cell lymphoma, subsets of adenocarcinoma of lung and breast, inflammatory myofibroblastic tumors. |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(14;16) | FISH | •Disease(s): Plasma cell myeloma (prognostic) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(4;14) | FISH | •Disease(s): Plasma cell neoplasms (prognostic) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| 13q abnormalities | FISH | •Disease(s): Myelodysplastic syndromes, plasma cell myeloma, B-lymphoid neoplasms (prognostic in myeloma and chronic lymphocytic leukemia) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| CEP 3/9 copy number | FISH | •Disease(s): Plasma cell neoplasms (prognostic) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| 1p/1q copy number | FISH | •Disease(s): Plasma cell neoplasms (prognostic) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| FOX01 | FISH | •Disease(s): Myelodysplastic Syndrome |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| EVI1 | FISH | •Disease(s): Myelodysplastic syndromes, acute myeloid leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| t(14;18) | FISH | •Disease(s): Follicular lymphoma, chronic lymphocytic leukemia (rare cases), classification and prognosis of aggressive B-cell lymphomas ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| 6q | FISH | •Disease(s): B-cell non-Hodgkin lymphoma and B-lymphoblastic leukemia; prognostic in lymphoplasmacytic lymphoma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| BCL6 | FISH | •Disease(s): B-cell non-Hodgkin lymphoma, classification and prognosis of aggressive B-cell lymphomas ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| FGFR1 | FISH | •Disease(s): Myeloid neoplasms associated with eosinophilia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| PDGFRβ | FISH | •Disease(s): Eosinophilia, Myeloproliferative Disease |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| PDGFRα | FISH | •Disease(s): Myeloid neoplasms associated with eosinophilia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x2 |
|
| 20q | FISH | •Disease(s): Myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, myeloproliferative neoplasms, plasma cell myeloma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(9;22)/Philadelphia Chromosome | FISH | •Disease(s): Chronic Myeloid Leukemia, Acute Lymphocytic Leukemia, Chronic Myelomonocytic Leukemia, Eosinophilia, Myeloproliferative Disease •Probes: |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x2 |
|
| IgH (BAP) | FISH | •Disease(s): B-lymphoid neoplasms, plasma cell neoplasms ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| RB1 | FISH | •Disease(s): Chronic lymphocytic leukemia – deletion of 13q involving RB1 locus has prognostic significance ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| Chromosome 12 | FISH | •Disease(s): Trisomy in chronic lymphocytic leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| ATM (copy number abnormalities) | FISH | •Disease(s): Lymphoid, myeloid and plasma cell neoplasms, prognostic ◦Probes for p53 and ATM may be ordered together or separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| p53 (copy number abnormalities) | FISH | •Disease(s): Lymphoid, myeloid and plasma cell neoplasms, prognostic. ◦Probes for p53 and ATM may be ordered together or separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(11;14) | FISH | •Disease(s): Mantle cell lymphoma, plasma cell myeloma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(15;17) PML/RARA | FISH | •Disease(s): Acute promyelocytic leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| CBFB rearrangement/inv(16) | FISH | •Disease(s): Acute myeloid leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| t(8;21) | FISH | •Disease(s): Acute myeloid leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| CEP8 | FISH | •Disease(s): Acute myeloid leukemia, myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, myeloproliferative neoplasms, including blast phase of CML ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| 7q | FISH | •Disease(s): Myelodysplastic syndromes, chronic myelomonocytic leukemia, acute myeloid leukemia, hepatosplenic T-cell lymphoma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| 5q/chr 5 abnormalities | FISH | •Disease(s): Myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, plasma cell myeloma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(8;14) | FISH | •Disease(s): Acute Lymphocytic Leukemia, Burkitt Lymphoma |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| p16 | FISH | •Disease(s): B-lymphoblastic leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x1 |
|
| t(9;22)/Philadelphia Chromosome | FISH | •Disease(s): Chronic myelogenous leukemia, B-lymphoblastic leukemia ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1, 88369x2 |
|
| T-Cell Lymphoma FISH Panel | FISH | •Disease(s): Peripheral T-cell lymphoma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x4) |
|
| Multiple Myeloma Prognostic Panel | FISH | •Disease(s): Abnormalities with prognostic significance in plasma cell myeloma ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x7), with a reflex to 88377(x9) |
|
| Myeloproliferative Disease (MPD) FISH Panel | FISH | •Disease(s): Myeloproliferative neoplasms ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x4) |
|
| Myelodysplastic Syndrome (MDS) FISH Panel | FISH | •Disease(s): Myelodysplastic syndromes and other myeloid neoplasms ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x9) |
|
| B-Cell Lymphoma FISH Panel | FISH | •Disease(s): Multiple subtypes of B-cell non-Hodgkin lymphoma |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x5) |
|
| Eosinophilia FISH Panel | FISH | •Disease(s): Myeloid and lymphoid neoplasms associated with eosinophilia ◦Probes may be ordered separately. |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x5) |
|
| Chronic Myelomonocyitc Leukemia (CMML) FISH Panel | FISH | •Disease(s): Abnormalities associated with chronic myelomonocytic leukemia and other myeloproliferative or myelodysplastic/myeloproliferative neoplasms; the panel includes BCR/ABL, which has to be excluded for a diagnosis of CMML (WHO criteria) ◦Probes may be ordered separately |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x5) |
|
| Chronic Myelogenous Leukemia (CML) FISH Panel | FISH | •Disease(s): Chronic myelogenous leukemia, including abnormalities associated with progression to accelerated and blast phase •Probes: |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x3) |
|
| Chronic Lymphocytic Leukemia (CLL) FISH Panel | FISH | •Disease(s): Chronic lymphocytic leukemia (prognostic abnormalities) |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x6) |
|
| Acute Myelogenous Leukemia (AML) FISH Panel | FISH | •Disease(s): Acute myeloid leukemia *Probe set used only there is suspicion for APL based on morphologic/flow cytometric evaluation |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x6); with Reflex 88377(x7) |
|
| Acute Lymphocytic Leukemia (ALL) (Adult) FISH Panel | FISH | •Disease(s): B-lymphoblastic leukemia (adult patients) |
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88377(x4) |
|
| TERC FISH | FISH | Disease: The cervical TERC FISH Test evaluates for cervical cells for chromosomal abnormalities (TERC gene amplification, increase in chromosome copy number) linked to cervical cancer. Studies have shown that at lease 90% of invasive cervical cancer cases have increased copy numbers of the telomerase gene (TERC), located at 3q26.2. Probes: TERC (3q26)/5p15/Copy Control 7/CDKN2A |
Acceptable specimen collection/transport containers are: |
Specimens can be shipped and stored at 2 - 30°C. If shipping temperatures exceeding 30°C are anticipated, use cool plack. Viability after transfer to collection/transport tube is: |
3-7 Days |
88368x1, 88369x1 |
|
| TMPRSS2:ERG Fusion | FISH | Disease: A genetic mutation seen in up to 50 percent of prostate cancers, in which the androgen-regulated gene TMPRSS2 is fused with the gene for the transcription factor ERG. Probes: ERG/HMGN1/DSCAM/ TMPRSS2 at 21q22.2 |
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each FISH test ordered. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
3 - 7 Days |
88377 |
|
| PTEN FISH | FISH | Disease: Loss of PTEN in prostatic adenocarcinoma is associated with biochemical recurrence, advanced tumor stage, high Gleason grade, and lymph node metastasis. Probes: CEP10/PTEN/WAPAL/FAS at 10q23.31 |
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each FISH test ordered. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
3 - 7 Days |
88377 |
|
| Bladder FISH | FISH | Disease: Transitional cell carcinoma of bladder is frequently associated with chromosomal alterations, including chromosomes 1, 3, ,5, 7, 9, 10, 17, and others, which may be detected with high sensitivity and specificity by FISH in exfoliated urothelial cells from urine samples. Results of the test are intended for use, in conjunction with current standard diagnostic procedures such as cystoscopy and urine cytology, as an aid for initial diagnosis of bladder cancer in patients with hematuria and subsequent monitoring for tumor recurrence in patients with a history of bladder cancer. Probes: CEP3/CEP7/CEP10/5p15.2 |
Voided urine mixed 2:1 (v:v) with recommended PreservCyt (Hologic) |
Specimen should be stored and transported refrigerated with a cool pack. |
3 - 5 Days |
88120 |
|
| Mixed-Lineage Leukemia (MLL) Gene Rearrangements | FISH | •Disease(s): B-lymphoblastic leukemia, Acute myeloid leukemia, Mixed phenotype acute leukemias •Probes: ◦Probes may be ordered separately |
• Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable. |
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. |
1-3 Days |
88368x1 |
|
| Methodology | Test Name | Test Description | Specimen Requirements | Storage and Transport | Specimen Rejection Criteria | Turn Around Time (TAT) | CPT Codes* |
*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
