Test Name: Acute Myelogenous Leukemia (AML) FISH Panel
•Disease(s): Acute myeloid leukemia
◦EGR1 5q31.2/TASR1 5p15.31 (5q)
◦RELN, ORC5L 7q22/TES 7q31 (7q)
◦MYC 8q24/CEP8 8p11.1-q11.1 (CEP8)
◦RUNX1T1 8q21.3/RUNX1 21q22 t(8;21)
◦MLL 11q23 (MLL)
◦CBFB 16q22 (CBFB)
◦PML 15q24.1/RARA 17q21 t(15;17)*
◦Probes may be ordered separately
*Probe set used only there is suspicion for APL based on morphologic/flow cytometric evaluation
•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral Blood: 2-4 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Bone Marrow Core Biopsy: 1-2cm core (length) Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.
Storage and Transport
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Specimen Rejection Criteria
Turn Around Time (TAT): 1-3 Days
CPT Codes*: 88377(x6); with Reflex 88377(x7)
*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.