Test Name: BCL-2

Methodology: IHC

Test Description

The BCL2 protein is strongly expressed in the cytoplasm of mantle zone B-lymphocytes and activated T-lymphocytes. It is also overexpressed as a result of t(14;18) in follicular lymphomas and a subset of aggressive B-cell lymphomas, and as a result of translocation independent overexpression in mantle cell lymphoma, CLL/SLL, subsets of marginal zone lymphomas, Hodgkin lymphoma. It is most useful in the work-up of B-cell lymphoma.

Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.

Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping

Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.

Turn Around Time (TAT): 2-3 Days

CPT Codes*: 88341, 88342, 88360

*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.