Test Name: Chronic Myelogenous Leukemia (CML) FISH Panel

Methodology: FISH

Test Description

•Disease(s):  Chronic myelogenous leukemia, including abnormalities associated with progression to accelerated and blast phase •Probes:
◦MYC 8q24/CEP8 8p11.1/IGH 14q32 t(8;14)
◦ABL1 9q34/BCR 22q11.2/ASSI 9q34 t(9;22)
◦p53 17p13/ATM 11q22.3
◦Probes may be ordered separately

Specimen Requirements

•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral Blood: 2-4 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Bone Marrow Core Biopsy: 1-2cm core (length) Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.

Storage and Transport

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. 

Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.

Turn Around Time (TAT): 1-3 Days

CPT Codes*: 88377(x3)

*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.