Test Name: E-Cadherin
E-cadherin is a calcium dependent transmembrane epithelial protein that promotes intercellular adhesion. E-cadherin can distinguish breast LCIS from DCIS in indeterminate cases. In addition, there is reduced expression in urothelial cancer and absent in gastric signet ring cell carcinoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.
Storage and Transport
Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping
Specimen Rejection Criteria
Turn Around Time (TAT): 2-3 Days
CPT Codes*: 88341, 88342, 88360
*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.