Test Name: HSV 1 & 2


Methodology: IHC


Test Description

This antibody reacts with Herpes Simplex Virus (HSV) 1 and 2. It reacts with major viral envelope glycoproteins and with core proteins. Infected biopsy tissues include esophagus, lung, liver, cervix and perianal region, as well as cytology specimens. HSV can also infect both the peripheral and central nervous system. Viral antigens may be detected in the cytoplasm and nucleus. Typically, HSV Type 1 infects tissues such as lung and esophagus and HSV Type 2 infects the genitals and anus. This antibody does not cross-react with cytomegalovirus, Epstein-Barr virus, or varicella zoster virus. This antibody is compatible with formalin fixation, however prolonged fixation can be detrimental to HSV staining.


Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.


Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping


Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.


Turn Around Time (TAT): 2-3 Days


CPT Codes*: 88341, 88342, 88360


*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.