Test Name: KAPPA

Methodology: IHC

Test Description

Immunoglobulin kappa light chain can be detected immunohistochemically in benign plasma cells present in polyclonal plasma cell expansions associated with chronic inflammatory infiltrates, where they are typically admixed with lambda+ plasma cells. Igkappa is also detected in clonal (Ig kappa restricted) plasma cells associated with plasma cell neoplasms (MGUS, myeloma), B-cell non-Hodgkin lymphoma with plasmacytic differentiation, plasmablastic B-cell lymphoma and aggressive B-cell lymphomas with immunoblastic differentiation. Igkappa is typically evaluated together withh Iglambda expression to determine light-chain restriction (clonality).

Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.

Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping

Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.

Turn Around Time (TAT): 2-3 Days

CPT Codes*: 88341, 88342, 88360

*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.