Test Name: MSH6


Methodology: IHC


Test Description

MSH6 is a DNA mismatch repair protein. Loss of MSH6 expression in carcinoma or adenoma cells, typically as a result of mutation in MSH6 or MSH2 genes, is associated with hereditary non-polyposis cancer syndrome (Lynch syndrome, Muir-Torre syndrome). Evaluation of MSH6 expression by immunohistochemistry in colorectal and endometrial adenocarcinomas, as well as in sebaceous neoplasms is of value in identifying patients with Lynch syndrome. This information is important in management of their neoplasms, as well as for lifelong monitoring and genetic counseling. This test may be performed on tumor samples individually, or as a part of the MMR panel.


Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.


Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping


Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.


Turn Around Time (TAT): 2-3 Days


CPT Codes*: 88341, 88342, 88360


*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.