Test Name: Multiple Myeloma Prognostic Panel


Methodology: FISH


Test Description

•Disease(s): Abnormalities with prognostic significance in plasma cell myeloma
•Probes:
◦IGHC 14q32.3 (IGH)
◦1q21/1p32.3 (1p1q)
◦CEP3 /CEP9 (CEP3/9)
◦EGR1 5q31.2/TASR1 5p15.31 (5q)
◦CCND1 11q13/IGH 14q32.3 [t(11;14)]
◦D13S319 13q14.2/13qter 13q34 (13q)
◦CEP17/p53 (17p13)
◦FGFR3 4p16.3/IGH 14q 32.3 t(4;14) REFLEX
◦MAF 16q23/IGH 14q32.3 t(14;16) REFLEX

◦Probes may be ordered separately


Specimen Requirements

•Bone Marrow Aspirate: 1-3 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral Blood: 2-4 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Bone Marrow Core Biopsy: 1-2cm core (length) Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.


Storage and Transport

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. 


Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.


Turn Around Time (TAT): 1-3 Days


CPT Codes*: 88377(x7), with a reflex to 88377(x9)


*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.