Test Name: PAX-5

Methodology: IHC

Test Description

PAX5 (B-cell-specific activator protein, BSAP), is expressed by normal B-lymphoid cells ranging from early B-cell progenitors to post-germinal center B-cells, and is lost at the plasma cell stage. PAX5 is expressed by all types of B-cell non-Hodgkin lymphoma, classical and nodular lymphocyte predominant Hodgkin lymphoma, precursor B-lymphoblastic leukemias, AML with t(8;21), as well as rare cases of peripheral T-cell lymphoma and Merkel cell tumors.

Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.

Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping

Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.

Turn Around Time (TAT): 2-3 Days

CPT Codes*: 88341, 88342, 88360

*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.