Test Name: S100

Methodology: IHC

Test Description

Z0311 labels glial cells in the brain and ependymal cells. Moreover, Schwann’s cells of the peripheral nervous system are positive. Among tumors of the human central and peripheral nervous system, a positive reaction is seen in schwannomas, ependydomas as well as in different grades of astrogliomas, also including glioblastomas. A large proportion of cells in human tumors originating from different salivary glands are stainable with anti-S100. S100 is present in almost all human benign and malignant melanocytic tumors of the skin and in metastases of human malignant melanomas. The antibody is a useful tool for the classification of S100-positive neoplasms. It is mandatory that antibodies to S100 are used together with a panel of other antibodies.

Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.

Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping

Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.

Turn Around Time (TAT): 2-3 Days

CPT Codes*: 88341, 88342, 88360

*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.