Test Name: SYNAPTOPHYSIN
Synaptophysin is a 38 kDa membrane glycoprotein expressed in neuroendocrine cells and neurons involved in transmission via synaptic vehicles. Despite its abundance, the function of synaptophysin remains largely unknown, however an effect on efficient endocytosis of synaptic vesicles has recently been reported.Synaptophysin is a useful marker for identification of neuroendocrine neoplasm, such as neuroendocrine lung tumors (e.g. carcinoid, atypic carcinoid, SCLC, LCNEC and non-small cell lung cancer), neuroendocrine tumors of the gastroenteropancreatic tract, e.g. neuroendocrine tumors (NETs), neuroendocrine carcinoma (NECs) and other epithelial neuroendocrine neoplasms such as pituitary adenomas, medullary thyroid carcinoma and parathyroid adenomas. The new clone DAK-SYNAP is raised against a recombinant immunogen corresponding to the C-terminal cytoplasmic domain of human synaptophysin.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.
Storage and Transport
Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping
Specimen Rejection Criteria
Turn Around Time (TAT): 2-3 Days
CPT Codes*: 88341, 88342, 88360
*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.