Test Name: TMPRSS2:ERG Fusion


Methodology: FISH


Test Description

Disease: A genetic mutation seen in up to 50 percent of prostate cancers, in which the androgen-regulated gene TMPRSS2 is fused with the gene for the transcription factor ERG.

Probes: ERG/HMGN1/DSCAM/ TMPRSS2 at 21q22.2


Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each FISH test ordered.


Storage and Transport

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. 


Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.


Turn Around Time (TAT): 3 - 7 Days


CPT Codes*: 88377


*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.