Test Name: WT1


Methodology: IHC


Test Description

WT1 is a gene involved in the induction of Wilms’ tumor, a pediatric renal malignancy. Wilms’ tumor 1 protein regulates transcription of other genes and can function both as a transcriptional activator and repressor. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilms’ tumors. WT1 expression has been demonstrated in the epithelial and blastemal components of Wilms’ tumors and in the majority of malignant mesotheliomas as well as the majority of acute leukemias.


Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 3-4 microns for each test/antibody ordered.


Storage and Transport

Use cold pack during transport of paraffin blocks and unstained slides. Cold pack should not be placed in direct contact with the specimen during shipping


Specimen Rejection Criteria

Click here to reference the specimen rejection criteria.


Turn Around Time (TAT): 2-3 Days


CPT Codes*: 88341, 88342, 88360


*The CPT codes provided with our Test Descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.